Unyte

Unite for paternity

Pro‐Sexual Nutrient for Male‐Sexual‐Dysfunction [FSSAI Category] Deranged libido, erection and orgasm are only a part of the male sexual dysfunction. However, many individuals in the present day scenario are unsuspecting victims of a disorder which destroys the life of males who are afflicted by this disorder. Premature ejaculation occurs when a man ejaculates sooner during sexual intercourse than he or his partner would like. Premature ejaculation is a common sexual complaint

Simplified diagnostic criteria for premature ejaculation

i. Ejaculation that always or nearly always occurs prior to or within about 1 min of vaginal penetration
ii. Inability to delay ejaculation on all, or nearly all, vaginal penetrations and
iii. Negative personal consequences, such as distress, bother, frustration and/or the avoidance of sexual intimacy

Symptoms of Premature Ejaculation [PE]

The primary symptom of premature ejaculation is the inability to delay ejaculation for more than one minute after penetration. Premature ejaculation can be classified as lifelong (primary) or acquired (secondary). Lifelong premature ejaculation occurs all or nearly all of the time beginning with the first sexual encounter. Acquired premature ejaculation has the same symptoms but develops after having previous sexual experiences without ejaculatory problems.

Possible Causes

The exact cause of premature ejaculation isn't known. While it was once thought to be only psychological, doctors now know premature ejaculation is more complicated and involves a complex interaction of psychological and biological factors.

Psychological Causes

Some doctors believe that early sexual experiences may establish a pattern that can be difficult to change later in life, Such as:
i. Situations in which the individual hurries to reach climax in order to avoid being discovered
ii. Guilty feelings that increase the individuals tendency to rush through sexual encounters

Other factors that can play a role in causing premature ejaculation include:
Erectile Dysfunction
Anxiety
Relationship Problems

Biological Causes

A number of biological factors may contribute to premature ejaculation, including:
i. Abnormal hormone levels
ii. Abnormal levels of chemicals called neurotransmitters in the human brain
iii. Abnormal reflex activity of the ejaculatory system
iv. Certain thyroid problems
v. Inflammation and infection of the prostate or urethra
vi. Inherited traits

Risk Factors

1. Erectile Dysfunction ‐ At increased risk of premature ejaculation if you occasionally or consistently have trouble getting or maintaining an erection. Fear of losing your erection may cause you to consciously or unconsciously hurry through sexual encounters.
2. Health Problems ‐ If you have a serious or chronic medical condition, such as heart disease, you may feel anxious during sex and may unknowingly rush to ejaculate.
3. Stress ‐ Emotional or mental strain in any area of your life can play a role in premature ejaculation, often limiting your ability to relax and focus during sexual encounters.

Premature Ejaculation Treatment

A range of drugs are currently used by clinicians for the management of PE including antidepressants, local anesthetic agents and phosphodiesterase type 5 inhibitors. Whether the medication is used regularly or on demand is an important consideration for patients when choosing the most appropriate drug for the treatment of their PE. An on‐demand drug offers the flexibility of using the medication just prior to sexual intercourse, thereby reducing the risks of side effects associated with the drug for the rest of the time. A recent introduction into the Indian market is a short acting on‐demand SSRI Dapoxetine. The major problem with this medication is that it has to be taken at least 1‐2 hours prior to the sexual act. In a country like India, planned sex is virtually impossible, as the culture and custom are different unlike the western world. Although many Physicians consider this drug relatively safe and with few side effects, the major side effects that have been observed are nausea, diarrhea, headache, dizziness, decreased libido, erectile dysfunction [ED] and severe delays in ejaculation on long term use. The successful use of a nutraceutical, Hypericum containing Hypericin and Hyperforin [St. John's Wort] in Psychiatry paved way for the use of this active ingredient in a recipe along with other ingredients such as Butea superba, Piper longum, Turnera diffusa and Crocus sativus for treating premature ejaculation. The safety profile of these ingredients has been documented and has produced good clinical results in individuals with PE. This combination of nutraceutical ingredients has been aptly titled Unyte. The combination, of these ingredients has improved patient compliance and also the need for multiple drug therapy, thereby eliminating the unwanted, adverse drug reactions.

Absorption

Despite the mechanism of action being elucidated for all the active ingredients, the absorption patterns of the Individual and the ingredients combined in Unyte have not been studied and documented.

Metabolism

The metabolism and metabolite excretion patterns of the individual and combined ingredients of Unyte have not been studied.

Carcinogenesis, Mutagenesis

The nutraceutical supplement Unyte has not been administered to pregnant or lactating women as the supplement is currently recommended only for males.

Warnings & Precautions

The ingredients of Unyte have been used for centuries, and their active principles for over 2‐3 decades. It is advisable to inquire with the patients if they have taken similar nutraceutical preparations or one or more ingredients of the preparation, to prevent any adverse events. Concurrent administration of synthetic drugs has resulted in drug interactions with no fatalities. The physician needs to be updated on the drug interactions mentioned in drug interactions. Although one or more of the individual ingredients contained in Unyte is being used in female sexual dysfunction, the drug should not be administered to pregnant or lactating mothers, as the effects of the nutraceutical supplement have not been studied in this population.

Adverse Drug Reactions

No serious adverse drug reactions have been reported with use of Unyte; however, in susceptible individuals, mild to moderate GI upset has been noted that usually resolves during the course of the treatment. Headache and anorgasmia have been reported in very high doses of 900 – 1500 mg of Hypericum per day.

Drug Interactions

Drug interactions of mild to moderate severity have been noted with Carbamazepine, Cyclosporine, Nifedepine, Theophylline, Midazolam, SSRIs, and consumption of alcohol.

Usage in Special Population

1. Pregnancy & Lactation – The use and effects of Unyte have not been studied in pregnancy and lactating mothers. 2. Pediatric Use – The use/ safety of Unyte has not been studied in pediatric population 3. Renal and Hepatic Insufficiency – During animal and human clinical studies, no changes were observed in either renal or hepatic parameters. However, it is advisable to avoid the use of Unyte in cases of hepatic or renal failure, as the absorption, metabolism, distribution and excretion patterns of the active ingredients have not been studied in these classes of patients.

Dosage and Administration

The recommended dosage of Unyte is 1‐2 Capsules at bedtime with warm milk for a minimum duration of 90 days and thereafter can be extended at the discretion of the treating physician. The vegetable capsule of Unyte should be swallowed whole and should not be opened or chewed as the active ingredients are in a pellet form in the capsule. A gap of 2‐3 hours must be maintained between the consumption of other medications and Unyte capsules to avoid drug interactions.

How Supplied

Each strip contains 10 Vegetable Capsules and each box contains 10 Strips of 10 Vegetable Capsules.

Storage

The carton must be stored at the ambient temperature mentioned on the carton, preferably at temperatures below 25⁰C, away from direct sunlight. Do not use the drug if the capsules are leaking or damaged.

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